منابع مشابه
What controls nucleosome positions?
The DNA of eukaryotic genomes is wrapped in nucleosomes, which strongly distort and occlude the DNA from access to most DNA-binding proteins. An understanding of the mechanisms that control nucleosome positioning along the DNA is thus essential to understanding the binding and action of proteins that carry out essential genetic functions. New genome-wide data on in vivo and in vitro nucleosome ...
متن کاملNucleosome Positioning with Set of Key Positions and Nucleosome Affinity
The formation and precise positioning of nucleosome in chromatin occupies a very important role of study in life process. Today, many researchers discover that the positioning where the location of a DNA sequence fragment wraps around a histone in genome is not random but regular. However, the positioning is closely relevant to the concrete sequence of core DNA. So in this paper, we analyzed th...
متن کاملEvolutionary footprints of nucleosome positions in yeast.
Using genome-wide maps of nucleosome positions in yeast, we have analyzed the influence of chromatin structure on the molecular evolution of genomic DNA. We have observed, on average, 10-15% lower substitution rates in linker regions than in nucleosomal DNA. This widespread local rate heterogeneity represents an evolutionary footprint of nucleosome positions and reveals that nucleosome organiza...
متن کاملGenome-wide “Re”-Modeling of Nucleosome Positions
Two recent studies mapped nucleosomes across the yeast and human genomes, teasing apart the relative contributions of DNA sequence and chromatin remodelers to nucleosome organization. These data suggest two emerging models: chromatin remodelers position nucleosomes around transcriptional start sites in yeast, and a few "locked" nucleosomes may serve as barriers from which nucleosome arrays eman...
متن کاملGene splice sites correlate with nucleosome positions.
Gene sequences in the vicinity of splice sites are found to possess dinucleotide periodicities, especially RR and YY, with the period close to the pitch of nucleosome DNA. This confirms previously reported findings about preferential positioning of splice junctions within the nucleosomes. The RR and YY dinucleotides oscillate counter-phase, i.e., their respective preferred positions are shifted...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2009
ISSN: 0168-9525
DOI: 10.1016/j.tig.2009.06.002